Innovation and digitalization is transforming the global economic and society structure. Technologies such as AI, blockchain, IoT.. are expected to dominate all sectors of the economy, including higher education. Universities worldwide advocate diverse initiatives, especially through linkages with corporates, SMEs and innovative startups in education, training as well as incubating. The seminar covers Vietnam and global innovation landscape, the role of universities in Industry 4.0, and examples of innovation development in domestic and international universities.